Anytime you can include variation in your day your brain is benefiting.
The human brain is complex, dynamic and thrives on making new connections. This is a significant human advantage.
Variation (physical, cognitive, creative, emotional) brings new information to your brain and creates new neural pathways. We can't predict how new neural connections will impact your reality but we know that they will.
Whether the variation of standing rather than sitting brings your more comfort physically or helps you solve a problem you have been wrestling with we can't know. Why not give variation a chance to work its "magic".